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KMID : 0350519930460010323
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Journal of Catholic Medical College
1993 Volume.46 No. 1 p.323 ~ p.329
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Morphologic Changes of the Olfactory Bulb in Cadmium Poisoning in Rats
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Abstract
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Cadmiu poisoning is known to result in disorder of olfactory function like anosmia, but the morphological aspect of the olfactory impairment has not been investigated. This study was designed to observe morphologic changes of the olfactory bulb induced
by cadmium poisoning in rat.
The experimental rats were given daily subcutaneous injection of 0.1% solution of cadmium chloride (1.7 mg/kg) for 3 weeks. The control group was injected with the same volume of normal saline solution. The control and experimental animals were
sacrificed 8 hours after the last injection. The olfactory bulbs were fixed with phophate-buffered 2.5% glutaraldehyde-2% glutaraldehyde-2% paraformaldehyde through cardiac perfusion. The olfactory bulbs were removed, postfixed in osmium tetroxide,
dehydrated and embedded in Epon 182. The ultrathin sections were stained with uranyl acetate and lead citrate, and subjected to transmission electron eletron microscopic examination.
@ES The results were as follows :
@EN 1. In the glomerular layer of the olfactory bulb, the axons of olfactory cells showed multiple electron-dense bodies which were thought to be phagolysosome. The dendrites which formed synapse with the axons revealed no abnormality.
2. In the other layers of the olfactory bulb including the external plexiform layer, the mitral body layer and the granule layer, no ultrastructural abnormality was found.
The above findings suggest that cadmium poisoning causes selective damage to the axons of the olfactory cells in the bulb and that the damaged organelles induce the formation of phagolysosomes by sautophagy. It is inferred that cadmium-induced
anosmia is mainly due to the selective damage of olfactory cell axons.
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